Treating NASH
There is a need for specific drugs to treat NASH. Lifestyles are rarely enough and for patients with advanced conditions this will not be sufficient. Several drugs with different mechanisms of action are in development to treat NASH. They are currently available only via protocols but this will change in the next few years. The challenge then will be to personalize the treatment.
Latest research on FGF21
Prof. Jörn Schattenberg on FGF 21 analogs in the treatment of NASH
Obeticholic acid Lance 2019 Younossi Regenerate trial
Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial Lancet 2019 Dec 14;394(10215):2184-2196.doi: 10.1016/S0140-6736(19)33041-7. Epub 2019 Dec […]
Read in full >Semaglutide. Phil Newsome New Engl J Med 2021
A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis N Engl J Med. 2021 Mar 25;384(12):1113-1124. doi: 10.1056/NEJMoa2028395.Epub 2020 Nov 13. Philip N Newsome, Kristine Buchholtz, Kenneth Cusi, Martin […]
Read in full >Farnesoid X nuclear receptor ligand obeticholic acid
For noncirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Neuschwander-Tetri BA. et al. Lancet. 2015 Mar 14; 385(9972): 956–965.
Read in full >Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN)
A multicentre, double-blind, randomised, placebo-controlled phase 2 study. Glucagon-like peptide-1 (GLP-1) analogues reduce hepatic steatosis, concentrations of liver enzymes, and insulin resistance in murine models […]
Read in full >Improvements in histologic features and diagnosis
Associated with improvement in fibrosis in nonalcoholic steatohepatitis: results from the nonalcoholic steatohepatitis clinical research network treatment trials. Brunt EM et al. Hepatology. 2019 Aug;70(2):522-531
Read in full >Emerging medical therapies for NAFLD and for alcoholic hepatitis.
Non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are currently the two most common liver diseases in the world. Alcoholic hepatitis (AH), a unique […]
Read in full >AASLD/EASL joint workshop
Report on the AASLD/EASL joint workshop on clinical trial endpoints in NAFLD. Rinella ME et al. J Hepatol. 2019 Jul 9
Read in full >The Natural History of Advanced Fibrosis Due to NASH
Progression of nonalcoholic steatohepatitis (NASH) is incompletely characterized. We analyzed data on longitudinal changes in liver histology, hepatic venous pressure gradient (HVPG), and serum markers […]
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