Treating NASH

There is a need for specific drugs to treat NASH. Lifestyles are rarely enough and for patients with advanced conditions this will not be sufficient. Several drugs with different mechanisms of action are in development to treat NASH. They are currently available only via protocols but this will change in the next few years. The challenge then will be to personalize the treatment.

Obeticholic acid Lance 2019 Younossi Regenerate trial

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial Lancet 2019 Dec 14;394(10215):2184-2196.doi: 10.1016/S0140-6736(19)33041-7. Epub 2019 Dec […]

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Semaglutide. Phil Newsome New Engl J Med 2021

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis N Engl J Med. 2021 Mar 25;384(12):1113-1124. doi: 10.1056/NEJMoa2028395.Epub 2020 Nov 13. Philip N Newsome, Kristine Buchholtz, Kenneth Cusi, Martin […]

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Farnesoid X nuclear receptor ligand obeticholic acid

For noncirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Neuschwander-Tetri BA. et al. Lancet. 2015 Mar 14; 385(9972): 956–965.

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Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN)

A multicentre, double-blind, randomised, placebo-controlled phase 2 study. Glucagon-like peptide-1 (GLP-1) analogues reduce hepatic steatosis, concentrations of liver enzymes, and insulin resistance in murine models […]

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Improvements in histologic features and diagnosis

Associated with improvement in fibrosis in nonalcoholic steatohepatitis: results from the nonalcoholic steatohepatitis clinical research network treatment trials. Brunt EM et al. Hepatology. 2019 Aug;70(2):522-531

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Emerging medical therapies for NAFLD and for alcoholic hepatitis.

Non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are currently the two most common liver diseases in the world. Alcoholic hepatitis (AH), a unique […]

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AASLD/EASL joint workshop

Report on the AASLD/EASL joint workshop on clinical trial endpoints in NAFLD. Rinella ME  et al. J Hepatol. 2019 Jul 9

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The Natural History of Advanced Fibrosis Due to NASH

Progression of nonalcoholic steatohepatitis (NASH) is incompletely characterized. We analyzed data on longitudinal changes in liver histology, hepatic venous pressure gradient (HVPG), and serum markers […]

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